Biology of Aging Portal

Genes
Name	Description
Neoplasms, Experimental	Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. MeSH Definition
Vascular Diseases	The vascular system is the body's network of blood vessels. It includes the arteries, veins and capillaries that carry blood to and from the heart. Problems of the vascular system are common and can be serious. Arteries can become thick and stiff, a problem called arteriosclerosis. Blood clots can clog vessels and block blood flow to the heart or brain. Weakened blood vessels can burst, causing bleeding inside the body. MedlinePlus health topic
Heart Diseases	Heart disease is the number one killer in the U.S. It is also a major cause of disability. The most common cause of heart disease is narrowing or blockage of the coronary arteries, the blood vessels that supply blood to the heart itself. This is called coronary artery disease and happens slowly over time. It's the major reason people have heart attacks. MedlinePlus health topic
Female Urogenital Diseases	Pathological processes of the female urinary tract and the reproductive system. MeSH Definition
Pathologic Processes	The abnormal mechanisms and forms involved in the dysfunctions of tissues and organs. MeSH Definition
Wounds and Injuries	Injury is damage or harm caused to the structure or function of the body caused by an outside agent or force, which may be physical or chemical. Injury may also refer to injured feelings or reputation rather than injuries to the body. A severe and perhaps life-threatening injury is called a physical trauma. Wikipedia
Neurologic Manifestations	Clinical signs and symptoms caused by nervous system injury or dysfunction. MeSH Definition
Postoperative Complications	Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. MeSH Definition
Infection	Infection is the general term for invasion and growth of microorganisms in bodily tissues. GHR - Glossary
Disease Attributes	Clinical characteristics of disease or illness. MeSH Definition
Gastrointestinal Diseases	All diseases that pertain to the gastrointestinal tract are labelled as digestive diseases. This includes diseases of the esophagus, stomach, first, second and third part of the duodenum, jejunum, ileum, the ileo-cecal complex, large intestine (ascending, transverse and descending colon) sigmoid colon and rectum. Wikipedia
Central Nervous System Diseases	Diseases of the Central Nervous System (CNS). The CNS contains the majority of the nervous system, and consists of the brain (in vertebrates which have brains), and the spinal cord. Together with the peripheral nervous system, it has a fundamental role in the control of behavior. The CNS is contained within the dorsal cavity, with the brain within the cranial cavity, and the spinal cord in the spinal cavity. The brain is also protected by the skull, and the spinal cord is, in vertebrates, also protected by the vertebrae. Wikipedia
Urologic Diseases	Pathological processes of the urinary tract in both males and females. MeSH Definition
Myocardial Ischemia	Ischaemic or ischemic heart disease (IHD), or myocardial ischemia, is a disease characterized by reduced blood supply to the heart muscle, usually due to coronary artery disease (atherosclerosis of the coronary arteries). Its risk increases with age, smoking, hypercholesterolemia (high cholesterol levels), diabetes, hypertension (high blood pressure) and is more common in men and those who have close relatives with ischaemic heart disease. Wikipedia
Pathological Conditions, Anatomical	An abnormal structural condition of the human body, usually macroscopic, that is common to a variety of different diseases. MeSH Definition
Bone Diseases	Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly throughout your life. There are many kinds of bone problems: Osteoporosis makes your bones weak and more likely to break. Osteogenesis imperfecta makes your bones brittle. Bones can also develop cancer. Other bone diseases are caused by poor nutrition, genetic factors or problems with the rate of bone growth or rebuilding. MedlinePlus health topic
Skin Diseases	Conditions that irritate, clog or inflame your skin can cause symptoms such as redness, swelling, burning and itching. Allergies, irritants, your genetic makeup and certain diseases and immune system problems can cause dermatitis, hives and other skin conditions. Many skin problems, such as acne, also affect your appearance. MedlinePlus health topic
Congenital Abnormalities	Malformations of organs or body parts during development in utero. MeSH Definition
Pain	Pain is a feeling triggered in the nervous system. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel pain in one area of your body, such as your back, abdomen or chest, or you may feel pain all over, such as when your muscles ache from the flu. MedlinePlus health topic
Hemorrhage	Bleeding or escape of blood from a vessel. GHR - Glossary
Sexually Transmitted Diseases	Sexually transmitted diseases (STDs) are infections that you can get from having sex with someone who has the infection. The causes of STDs are bacteria, parasites and viruses. There are more than 20 types of STDs. MedlinePlus health topic
Lung Diseases	When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. The cells in your body need oxygen to work and grow. During a normal day, you breathe nearly 25,000 times. People with lung disease have difficulty breathing. Millions of people in the U.S. have lung disease. If all types of lung disease are lumped together, it is the number three killer in the United States. MedlinePlus health topic
Pregnancy Complications	Complications of pregnancy are the symptoms and problems that are associated with pregnancy. There are both routine problems and serious, even potentially fatal problems. The routine problems are normal complications, and pose no significant danger to either the woman or the fetus. Serious problems can cause both maternal death and fetal death if untreated. Wikipedia
Kidney Diseases	Your kidneys are two bean-shaped organs, each about the size of your fists. They are located near the middle of your back, just below the rib cage. Inside each kidney about a million tiny structures called nephrons filter blood. They remove waste products and extra water, which become urine. The urine flows through tubes called ureters to your bladder, which stores the urine until you go to the bathroom. Damage to the nephrons results in kidney disease. This damage may leave kidneys unable to remove wastes. Usually the damage occurs slowly over years. MedlinePlus health topic
Cerebrovascular Disorders	Cerebrovascular disease is a group of brain dysfunctions related to disease of blood vessels supplying the brain. Hypertension is the most important cause that damages the blood vessel lining endothelium exposing the underlying collagen where platelets aggregate to initiate a repairing process which is not always complete and perfect. Sustained hypertension permanently changes the architecture of the blood vessels making them narrow, stiff, deformed and uneven which are more vulnerable to fluctuations of blood pressure. A fall in blood pressure during sleep can lead to marked reduction in blood flow in the narrowed blood vessels causing ischemic stroke in the morning whereas a sudden rise in blood pressure can cause tearing of the blood vessels causing intracranial hemorrhage during excitation at daytime. Primarily people who are elderly, diabetic, smoker, or have ischemic heart disease, have cerebrovascular disease. All diseases related to artery dysfunction can be classified under a disease as known as Macrovascular disease. This is a simplistic study by which arteries are blocked by fatty deposits or by a blood clot. The results of cerebrovascular disease can include a stroke, or even sometimes a hemorrhagic stroke. Ischemia or other blood vessel dysfunctions can affect one during a cerebrovascular accident. Wikipedia
Genital Diseases, Female	Pathological processes involving the female reproductive tract. MeSH Definition
Neoplasms by Site	A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as brain neoplasms, duodenal neoplasms, etc. MeSH Definition
Metabolic Diseases	Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. MeSH Definition
Coronary Disease	Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death in the United States in both men and women. MedlinePlus health topic
Lentivirus Infections	Infection by lentivirus. Lentivirus is a genus of slow viruses of the Retroviridae family, characterized by a long incubation period. Wikipedia

Neoplasms, Experimental

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. MeSH Definition

Vascular Diseases

The vascular system is the body's network of blood vessels. It includes the arteries, veins and capillaries that carry blood to and from the heart. Problems of the vascular system are common and can be serious. Arteries can become thick and stiff, a problem called arteriosclerosis. Blood clots can clog vessels and block blood flow to the heart or brain. Weakened blood vessels can burst, causing bleeding inside the body. MedlinePlus health topic

Heart Diseases

Heart disease is the number one killer in the U.S. It is also a major cause of disability. The most common cause of heart disease is narrowing or blockage of the coronary arteries, the blood vessels that supply blood to the heart itself. This is called coronary artery disease and happens slowly over time. It's the major reason people have heart attacks. MedlinePlus health topic

Female Urogenital Diseases

Pathological processes of the female urinary tract and the reproductive system. MeSH Definition

Pathologic Processes

The abnormal mechanisms and forms involved in the dysfunctions of tissues and organs. MeSH Definition

Wounds and Injuries

Injury is damage or harm caused to the structure or function of the body caused by an outside agent or force, which may be physical or chemical. Injury may also refer to injured feelings or reputation rather than injuries to the body. A severe and perhaps life-threatening injury is called a physical trauma. Wikipedia

Neurologic Manifestations

Clinical signs and symptoms caused by nervous system injury or dysfunction. MeSH Definition

Postoperative Complications

Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. MeSH Definition

Infection

Infection is the general term for invasion and growth of microorganisms in bodily tissues. GHR - Glossary

Disease Attributes

Clinical characteristics of disease or illness. MeSH Definition

Gastrointestinal Diseases

All diseases that pertain to the gastrointestinal tract are labelled as digestive diseases. This includes diseases of the esophagus, stomach, first, second and third part of the duodenum, jejunum, ileum, the ileo-cecal complex, large intestine (ascending, transverse and descending colon) sigmoid colon and rectum. Wikipedia

Central Nervous System Diseases

Diseases of the Central Nervous System (CNS). The CNS contains the majority of the nervous system, and consists of the brain (in vertebrates which have brains), and the spinal cord. Together with the peripheral nervous system, it has a fundamental role in the control of behavior. The CNS is contained within the dorsal cavity, with the brain within the cranial cavity, and the spinal cord in the spinal cavity. The brain is also protected by the skull, and the spinal cord is, in vertebrates, also protected by the vertebrae. Wikipedia

Urologic Diseases

Pathological processes of the urinary tract in both males and females. MeSH Definition

Myocardial Ischemia

Ischaemic or ischemic heart disease (IHD), or myocardial ischemia, is a disease characterized by reduced blood supply to the heart muscle, usually due to coronary artery disease (atherosclerosis of the coronary arteries). Its risk increases with age, smoking, hypercholesterolemia (high cholesterol levels), diabetes, hypertension (high blood pressure) and is more common in men and those who have close relatives with ischaemic heart disease. Wikipedia

Pathological Conditions, Anatomical

An abnormal structural condition of the human body, usually macroscopic, that is common to a variety of different diseases. MeSH Definition

Bone Diseases

Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly throughout your life. There are many kinds of bone problems: Osteoporosis makes your bones weak and more likely to break. Osteogenesis imperfecta makes your bones brittle. Bones can also develop cancer. Other bone diseases are caused by poor nutrition, genetic factors or problems with the rate of bone growth or rebuilding. MedlinePlus health topic

Skin Diseases

Conditions that irritate, clog or inflame your skin can cause symptoms such as redness, swelling, burning and itching. Allergies, irritants, your genetic makeup and certain diseases and immune system problems can cause dermatitis, hives and other skin conditions. Many skin problems, such as acne, also affect your appearance. MedlinePlus health topic

Congenital Abnormalities

Malformations of organs or body parts during development in utero. MeSH Definition

Pain

Pain is a feeling triggered in the nervous system. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel pain in one area of your body, such as your back, abdomen or chest, or you may feel pain all over, such as when your muscles ache from the flu. MedlinePlus health topic

Hemorrhage

Bleeding or escape of blood from a vessel. GHR - Glossary

Sexually Transmitted Diseases

Sexually transmitted diseases (STDs) are infections that you can get from having sex with someone who has the infection. The causes of STDs are bacteria, parasites and viruses. There are more than 20 types of STDs. MedlinePlus health topic

Lung Diseases

When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. The cells in your body need oxygen to work and grow. During a normal day, you breathe nearly 25,000 times. People with lung disease have difficulty breathing. Millions of people in the U.S. have lung disease. If all types of lung disease are lumped together, it is the number three killer in the United States. MedlinePlus health topic

Pregnancy Complications

Complications of pregnancy are the symptoms and problems that are associated with pregnancy. There are both routine problems and serious, even potentially fatal problems. The routine problems are normal complications, and pose no significant danger to either the woman or the fetus. Serious problems can cause both maternal death and fetal death if untreated. Wikipedia

Kidney Diseases

Your kidneys are two bean-shaped organs, each about the size of your fists. They are located near the middle of your back, just below the rib cage. Inside each kidney about a million tiny structures called nephrons filter blood. They remove waste products and extra water, which become urine. The urine flows through tubes called ureters to your bladder, which stores the urine until you go to the bathroom. Damage to the nephrons results in kidney disease. This damage may leave kidneys unable to remove wastes. Usually the damage occurs slowly over years. MedlinePlus health topic

Cerebrovascular Disorders

Cerebrovascular disease is a group of brain dysfunctions related to disease of blood vessels supplying the brain. Hypertension is the most important cause that damages the blood vessel lining endothelium exposing the underlying collagen where platelets aggregate to initiate a repairing process which is not always complete and perfect. Sustained hypertension permanently changes the architecture of the blood vessels making them narrow, stiff, deformed and uneven which are more vulnerable to fluctuations of blood pressure. A fall in blood pressure during sleep can lead to marked reduction in blood flow in the narrowed blood vessels causing ischemic stroke in the morning whereas a sudden rise in blood pressure can cause tearing of the blood vessels causing intracranial hemorrhage during excitation at daytime. Primarily people who are elderly, diabetic, smoker, or have ischemic heart disease, have cerebrovascular disease. All diseases related to artery dysfunction can be classified under a disease as known as Macrovascular disease. This is a simplistic study by which arteries are blocked by fatty deposits or by a blood clot. The results of cerebrovascular disease can include a stroke, or even sometimes a hemorrhagic stroke. Ischemia or other blood vessel dysfunctions can affect one during a cerebrovascular accident. Wikipedia

Genital Diseases, Female

Pathological processes involving the female reproductive tract. MeSH Definition

Neoplasms by Site

A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as brain neoplasms, duodenal neoplasms, etc. MeSH Definition

Metabolic Diseases

Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. MeSH Definition

Coronary Disease

Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death in the United States in both men and women. MedlinePlus health topic

Lentivirus Infections

Infection by lentivirus. Lentivirus is a genus of slow viruses of the Retroviridae family, characterized by a long incubation period. Wikipedia

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